Regulation of Urokinase Receptor Proteolytic Function by the Tetraspanin CD82

Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored cellular receptor (uPAR) promotes plasminogen activation and the efficient generation of pericellular proteolytic activity. We demonstrate here that expression of the tetraspanin CD82/KAI1 (a tumor metastasis suppressor) leads to a profound effect on uPAR function. Pericellular plasm...

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

The 'metastasis suppressor' CD82/KAI-1, a member of the tetraspanin superfamily of transmembrane proteins, is widely distributed in normal tissues [1], and has been shown to be suppressed in the advanced stages of various epithelial malignancies [2-6]. Although the physiological relevance of this change is unknown, in vitro data show that ectopically expressed CD82/KAI-1 can suppress tumor cell...

Neutrophil Elastase and Cathepsin G Receptor/CD87 on Monocytic Cells by Proteolytic Regulation of the Urokinase

rehabilitation of the oral function of edentulous patient by implants توانبخشی کارکرد خوراک در بیماران بی دندان توسط ایمپلنت

چکیده ندارد.

Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR.

We have previously shown that CD82, a transmembrane protein of the tetraspanin superfamily is associated with EGFR and has a negative effect on EGF-induced signalling (Odintsova, E., Sugiura, T. and Berditchevski, F. (2000) Curr. Biol. 10, 1009-1012). Here we demonstrate that CD82 specifically attenuates ligand-induced dimerization of EGFR. The recombinant soluble large extracellular loop of CD...